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Liver Center - Xiaofeng Fan, MD, PhD

Xiaofeng Fan, MD, PhD

Dr. Fan joined the faculty of Saint Louis University Medical Center in June 2000 having worked with Dr. Di Bisceglie since 1996. His major research interests are molecular virology of hepatitis C: viral mutation and evolutionary biotechnology and antibody engineering: humanized antibodies and their clinical applications.


Nanjing Medical University
China, 1987.

Internal Medicine
Nanjing Medical University Hospital, 1987-1990

Infectious Diseases
Nanjing Medical University Hospital, 1991-1993

Postdoctoral fellow:
Clinical virology
Queen's Medical Center
Nottingham University, England, 1995-1996.

Postdoctoral fellow:
Molecular virology
Saint Louis University
Missouri, 1996-2000

Recent Activities:

  1. Wang W, Ren R, Xu Y, Di Bisceglie AM, Fan X. Template-dependent multiple displacement amplification applied to circulating RNA profiling. 2017. Under review
  2. Ren Y, Wang W, Zhang X, Xu Y, Di Bisceglie AM, Fan X. Evidence for deleterious hepatitis C virus quasispecies mutation loads that differentiate the response patterns in IFN-based antiviral therapy. Journal of General Virology 2016; 97(2):334-43.
  3. Lin J, Wang W, Xu Y, Di Bisceglie AM, Fan X. Patterns of longitudinal change in hepatitis C virus neutralization titers correlate with the outcome of peginterferon and ribavirin combination therapy. Journal of Medical Virology. 2015; 87(5):821-8.
  4. Wang W, Zhang X, Xu Y, Weinstock GM, Di Bisceglie AM, Fan X. High-resolution quantification of hepatitis C virus genome-wide mutation load and its correlation with the outcome of peginterferon-alpha2a and ribavirin combination therapy. PloS One 2014; 9(6):e100131.
  5. Wang W, Zhang X, Xu Y, Di Bisceglie AM, Fan X. Viral categorization and discovery in human circulation by transcriptome sequencing. Biochem Biophys Res Commun. 2013; 436(3):525-9.
  6. Lu Y, Xu Y, Di Bisceglie AM, Fan X. Comprehensive cloning of patient-derived 9022-bp amplicons of hepatitis C virus. Journal of Virological Methods 2013; 191(2):105-12.
  7. Wang W, Lin J, Tan D, Xu Y, Brunt EM, Fan X, Di Bisceglie AM. Divergent quasispecies evolution in de novo hepatitis C virus infection associated with bone marrow transplantation. Biochem Biophys Res Commun. 2011; 414(1):148-52.
  8. Tavis JE, Donlin MJ, Aurora R, Fan X, Di Bisceglie AM. Prospects for personalizing antiviral therapy for hepatitis C virus with pharmacogenetics. Genome Medicine 2011; 3(2):8.
  9. Zhang X, Ryu SH, Xu Y, Elbaz T, Zekri AR, Abdelaziz AO, Abdel-Hamid M, Thiers V, Elena SF, Fan X, Di Bisceglie AM. The Core/E1 domain of hepatitis C virus genotype 4a in Egypt does not contain viral mutations or strains specific for hepatocellular carcinoma. Journal of Clinical Virology 2011; 52(4):333-8.

Current Address

Saint Louis University School of Medicine
3635 Vista Avenue at Grand Boulevard
P.O. Box 15250
St. Louis, Missouri 63110-0250

Contact Information

Laboratory No: (314) 977-7833
Fax: 314-977-9909

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