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Liver Center - Wilson Disease

Definition Incidence Risk Factors/Cause
The inability of copper to be excreted in bile causing its accumulation in the liver, brain, kidneys and cornea. Adolescents and young adults

Autosomal inherited disease
Symptoms Diagnosis Treatment/Prevention
Accumulation of copper in liver tissue

Hemolytic anemia

Low ceruloplasmin

Neurologic impairments

Kayser-Fleischer rings
Medical history

Physical exam

Blood tests

Liver biopsy
Penicillamine, trientine or zinc therapy

Prednisone therapy

Liver transplantation in severe, chronic cases