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Liver Center - William S. Wold, PhD

William S. Wold, PhD

Dr. William S. M. Wold received his Ph.D. in 1973 from the University of Manitoba, Winnipeg, Canada. He joined the faculty of Saint Louis University in 1973, and is currently Professor and Chairman of the Department of Molecular Microbiology & Immunology in the Saint Louis University School of Medicine.

Building on the long tradition of adenovirus molecular virology at Saint Louis University, Dr. Wold’s laboratory has participated in the discovery of a new class of viral proteins that orchestrate the life and death of adenovirus infected human cells. Several of these adenovirus proteins counteract host immunosurveillance by preventing immune killer cells from destroying infected cells. At the culmination of infection, a unique protein, termed Adenovirus Death Protein (ADP), promotes cell death thereby allowing virus to be released from cells. Dr. Wold is investigating how these adenovirus proteins function; they represent powerful tools to unravel the complexities of virus infections. Dr. Wold is also developing ADP-based replication-competent genetically-engineered adenovirus “vectors” for cancer gene therapy. These vectors destroy cells in cancerous tumors but have minimal effect on non-cancerous cells. Dr. Wold is attempting to employ one of these vectors as a drug to treat cancer in humans.


Professor & Chairman
Molecular Microbiology & Immunology

University of Manitoba
Winnipeg, Canada, 1973

Current Address

Saint Louis University School of Medicine
Edward A. Doisy Research Center
1100 S. Grand Blvd., Room 733
St. Louis, Missouri 63104
Office: 314-977-8857
Fax: 314-977-8717

Contact Information