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Liver Center - William S. Sly, MD

William S. Sly, MD


An internationally renowned physician and scientist, William S. Sly, M.D., has contributed greatly to the understanding of inborn errors of metabolism. These inherited disorders cause biological substances to collect within tissues and organs, interfering with normal function. Sly has uncovered the genetic and biochemical foundations of several rare, yet devastating diseases and helped introduce promising new treatment options. Sly did his undergraduate work at Saint Louis University and obtained his medical degree from the university’s School of Medicine in 1957.

Sly was appointed the Alice A. Doisy Professor and Chairman of the Edward A. Doisy Department of Biochemistry and Molecular Biology at Saint Louis University in 1984. In February 2007, he was also named the inaugural holder of the James B. and Joan C. Peter Endowed Chair in Biochemistry and Molecular Biology.

In 1973, Sly and his research group described the first patient with mucopolysaccharidosis VII, later termed Sly syndrome. This research provided the rationale for enzyme replacement therapy in Gaucher’s disease, the most common lysosomal storage disease, and has encouraged the development of enzyme replacement for other lysosomal diseases. Sly’s work on lysosomal storage disorders led to his election to the National Academy of Sciences in 1989.

Sly also identified the first inherited deficiency of a human carbonic anhydrase and characterized the associated bone, brain, and kidney disease. In addition, he has conducted extensive research on hereditary hemochromatosis.

Current Address

Saint Louis University School of Medicine
1100 South Grand Boulevard
Doisy Research Center
Room 533
St. Louis, Missouri 63104

Contact Information

Phone: 314-977-9201
Fax: 314-577-8125

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