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Liver Center - Primary Sclerosing Cholangitis (PSC)

Definition Incidence Risk Factors/Cause
A disease in which bile ducts inside and outside the liver become inflamed and scarred causing bile build up and damage to liver tissue. 1 to 3 in 100,000 worldwide History of inflammatory bowel disease

More common in men
Symptoms Diagnosis Treatment/Prevention

Severe itching

Fever and chills


Abdominal pain
Medical history

Physical exam Blood tests

Endoscopic retrograde cholangiopancreato-graphy (ERCP)

Liver biopsy
No currently accepted medical therapy

Medical treatment for itching, infections and vitamin deficiency

Surgical management of biliary blockages

Liver transplantation in severe, chronic cases