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Liver Center - Primary Biliary Cirrhosis (PBC)



Definition Incidence Risk Factors/Cause
A disease that slowly destroys the bile ducts in the liver causing bile build up and damage to liver tissue. 6 in 100,000 worldwide
1 in 1000 in Scandinavia, Scotland and Northern England
More common in women
Symptoms Diagnosis Treatment/Prevention
Severe itching
Fatigue
High cholesterol
Hyperpigmentation
Osteoporosis
Jaundice
Ascites
Dry eyes or mouth
Portal hypertension
Medical history
Physical exam
Blood tests
X-rays
Liver biopsy
Medical therapy with ursodeoxycholic acid

Liver transplantation in severe cases

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